Science: HK2 - A Major Driver of Cancer

cancerdriver

VDA-1102 VDAC/HK2 MOA

HKS N-terminal-helix flips out of place to allow VDAC's N-terminal-helix to replace it, thus binding the two proteins.
cancerdriver

VDA-1102 Inhibits Cancer Proliferation

VDA-1102 demonstrated strong inhibition of cancer growth across multiple indications.

70% of a panel with 57 cancer models (2019-2021)

Threshold <2uM; Colony forming assay in 57 patient-derived tumors and cancer cell lines conducted at Oncotest GmbH, a division of Charles River Labs.